CircRNA-based, non-integrated, in vivo panCAR-mediated B cell immune resetting in mouse models and non-human primates
Yanyan Wang, Xinyue Wang, Qian Pan, Haomeng Kou, Chi Zhang, Shengnan She, Jie Yin, Xinyuan Liao, Wanjia Wang, Ligaoyue Zhang, Huji Xu, Tianlei Ying, Yanling Wu, Liang Qu
This paper develops circRNA-based in vivo panCAR to achieve comprehensive B cell depletion and reconstitution, showing efficacy in treating B cell disorders and aging in mice and non-human primates.
bioRxiv · Aug 11, 2025 · PreprintImmunology