Cancer BiologybioRxivPreprint
Overcoming migratory exhaustion: Expression of Matrix metalloproteinase-8 (MMP-8) promotes tumor infiltration and anti-tumor activity of CAR-T cells
Irfan N. Bandey, Melisa J. Montalvo, Harjeet Singh, Navin Varadarajan
This study shows that CAR-T cells engineered to secrete MMP-8 enhance tumor infiltration and anti-tumor activity in solid tumors.
DOI 10.1101/2023.06.21.545815