Author

Harper E. Smith

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Ángela BallesterosiD· 2 shared Marcos M. SotomayoriD· 2 shared Haosheng WeniD· 1 shared Hubert LeeiD· 1 shared Jayashree BalaramaniD· 1 shared Runjia Cui· 1 shared Travis Harrison-Rawn· 1 shared Wang ZhengiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Ángela BallesterosORCID

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2 papers

Recent·Most cited

TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells

Hubert Lee, Yein Christina Park, Haosheng Wen, Harper E. Smith, Jayashree Balaraman, Runjia Cui, Marcos M. Sotomayor, Ángela Ballesteros

This study identifies TMC1 and TMC2 as cholesterol-dependent lipid scramblases that regulate membrane homeostasis in auditory hair cells, linking their dysfunction to hereditary deafness.

bioRxiv · Jul 3, 2025 · PreprintNeuroscience

Groove architecture controls lipid scrambling in simulations of protein and model systems

Harper E. Smith, Travis Harrison-Rawn, Wang Zheng, Ángela Ballesteros, Marcos M. Sotomayor

This study uses simulations to show that groove architecture, not amino acid sequence, determines lipid scrambling in scramblase proteins.

bioRxiv · Jun 27, 2025 · PreprintBiophysics