Ángela Ballesteros

This study identifies TMC1 and TMC2 as cholesterol-dependent lipid scramblases that regulate membrane homeostasis in auditory hair cells, linking their dysfunction to hereditary deafness.

This study uses simulations to show that groove architecture, not amino acid sequence, determines lipid scrambling in scramblase proteins.

This study shows that PIP2-Tmie interactions, not myosin motors, drive slow adaptation in mammalian hair cells, as demonstrated by rescue experiments and disruption studies.

The paper identifies TMC4 and TMC5 at microvillar tips and suggests they may function as ion channels and lipid scramblases, similar to mechanotransduction complexes in stereocilia.

The paper presents a large annotated dataset of cochlear hair cells for machine learning applications in hearing research.

This study shows TMC1, but not TMC2, is essential for membrane remodeling in response to calcium changes, and mutations in TMC1 disrupt membrane homeostasis, leading to hearing loss.