Conditional deletion of CEACAM1 causes hepatic stellate cell activation
Harrison T. Muturi, Hilda E. Ghadieh, Suman Asalla, Sumona Ghosh Lester, Getachew Debas Belew, Sobia Zaidi, Raziyeh Abdolahipour, Abhishek P Shrestha, Agnes O Portuphy, Hannah L. Stankus, Raghd Abu Helal, Stefaan Verhulst, Sérgio M. Duarte, Ali Zarrinpar, Leo A. van Grunsven, , Sonia Michael Najjar
This study shows that CEACAM1 loss in hepatic stellate cells (HSCs) activates them, leading to myofibroblastic transformation and fibrosis without insulin resistance or steatosis.
Molecular Metabolism · Aug 19, 2024Peer-reviewedPhysiology