Aging-Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment
Mary Priyanka Udumula, Km Anjaly, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather Marie Gibson, Ramandeep Rattan
This study identifies succinate accumulation in aged ovarian tumor microenvironments as a driver of Treg dysfunction, suggesting metabolic targeting as a strategy to restore antitumor immunity.
Aging Cell · Apr 24, 2026Peer-reviewedImmunology