Mohammad Nematullah

This study identifies succinate accumulation in aged ovarian tumor microenvironments as a driver of Treg dysfunction, suggesting metabolic targeting as a strategy to restore antitumor immunity.

This study identifies Irg1 as a protective gene that negatively regulates pathogenic Th17 cells in CNS autoimmunity using knockout mice and single-cell RNA sequencing.

This study shows that loss of AMPK after traumatic brain injury in mice worsens inflammation and behavioral outcomes by increasing inflammasome activation and proinflammatory cytokines.

This study shows that MaR1 treatment reduces inflammation, protects neurons, and improves metabolism in a mouse model of multiple sclerosis.