William A. Goddard

This study identifies a tRNA-derived small RNA that reduces cardiac fibrosis and hypertrophy through cell-type-specific mechanisms in mouse and human cardiac cells.

This study shows HMCES-DPC formation increases DNA template flexibility, enabling slippage and mutagenic bypass of AP sites during replication.

This paper develops a conditional-siRNA system that targets calcineurin in cardiac cells to reduce hypertrophy by responding to nppa mRNA, showing specific activation under stress conditions.

The paper shows that bystander base editing with ABE8e impairs visual function restoration in LCA model mice by causing structural and functional disruptions in RPE65.