Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors
Deepak Kumar Mishra, Shelli M. Morris, Dean Popovski, Emily J. Girard, Andrew Bondoc, Shiva Senthil Kumar, Augusto Faria Andrade, Xiaoting Zhu, Fupan Yao, Mi‐Youn Brusniak, Banlanjo Abdulaziz Umaru, Erin E. Crotty, Kenneth Brasel, Fiona J. Pakiam, Caterina Russo, , Rachid Drissi
This study investigates the combination of DNA methyltransferase inhibitor decitabine and PD-1 inhibitor in high-risk pediatric brain tumor models, finding improved survival in some subtypes.
bioRxiv · May 14, 2025 · PreprintImmunology