Author

Shiva Senthil Kumar

Nationwide Children's HospitalORCID 0000-0002-8546-9734Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Banlanjo Abdulaziz UmaruiD· 3 shared Rachid DrissiiD· 3 shared Deepak Kumar Mishra· 2 shared Maryam FouladiiD· 2 shared Andrew BondociD· 1 shared Annie HuangiD· 1 shared Arzu Onar-Thomas· 1 shared Ashley MargoliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Banlanjo Abdulaziz UmaruORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

hTERT Expression, Regulation, and Prognostic Significance in Pediatric Medulloblastoma

Ryuma Tanaka, Banlanjo Abdulaziz Umaru, Matthew Sobo, Shiva Senthil Kumar, Kathleen McCarthy O'Toole Dorris, Volker Hovestadt, Vijay Ramaswamy, Marc Remke, Ashley Margol, Charles B. Stevenson, Shahab Asgharzadeh, Stewart Goldman, Lili Miles, Jie Huang, Katja von Hoff, , Rachid Drissi

This study examines hTERT expression and its prognostic impact in pediatric medulloblastoma, finding higher expression correlates with worse survival outcomes.

bioRxiv · May 6, 2026 · PreprintCancer Biology

BMI-1 Modulation and Trafficking During M Phase in Diffuse Intrinsic Pontine Glioma

Banlanjo Abdulaziz Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi

This study shows BMI-1 phosphorylation in DIPG cells during M phase leads to cytoplasmic translocation via CRM1-mediated nuclear export.

FEBS Open Bio · Dec 27, 2025Peer-reviewedCancer Biology

Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors

Deepak Kumar Mishra, Shelli M. Morris, Dean Popovski, Emily J. Girard, Andrew Bondoc, Shiva Senthil Kumar, Augusto Faria Andrade, Xiaoting Zhu, Fupan Yao, Mi‐Youn Brusniak, Banlanjo Abdulaziz Umaru, Erin E. Crotty, Kenneth Brasel, Fiona J. Pakiam, Caterina Russo, , Rachid Drissi

This study investigates the combination of DNA methyltransferase inhibitor decitabine and PD-1 inhibitor in high-risk pediatric brain tumor models, finding improved survival in some subtypes.

bioRxiv · May 14, 2025 · PreprintImmunology