Author

Annie Huang

Brown UniversityORCID 0000-0002-1987-6980Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Erica LarschaniD· 2 shared Nicolas Lux FawziiD· 2 shared Alexander E. ConicellaiD· 1 shared Andrew BondociD· 1 shared Ashley Mae ConardiD· 1 shared Augusto Faria AndradeiD· 1 shared Banlanjo Abdulaziz UmaruiD· 1 shared Boyang LiiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenomics

Erica LarschanORCID

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4 papers

Recent·Most cited

TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer's disease

Neil Victor Yang, Shaowei Wang, Boyang Li, Jeffrey A. Simms, Linsey Dinh, Annie Huang, Jacob H Oei, Hussein N. Yassine, Ronald M. Krauss

This study shows that TOMM40 suppression leads to cholesterol imbalance and AD-like molecular and behavioral changes in mice and human neurons.

Alzheimer s & Dementia · Apr 1, 2026Peer-reviewedMolecular Biology

Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors

Deepak Kumar Mishra, Shelli M. Morris, Dean Popovski, Emily J. Girard, Andrew Bondoc, Shiva Senthil Kumar, Augusto Faria Andrade, Xiaoting Zhu, Fupan Yao, Mi‐Youn Brusniak, Banlanjo Abdulaziz Umaru, Erin E. Crotty, Kenneth Brasel, Fiona J. Pakiam, Caterina Russo, , Rachid Drissi

This study investigates the combination of DNA methyltransferase inhibitor decitabine and PD-1 inhibitor in high-risk pediatric brain tumor models, finding improved survival in some subtypes.

bioRxiv · May 14, 2025 · PreprintImmunology

A dual DNA/RNA-binding factor regulates co-transcriptional splicing through target RNA interaction and modulates splicing factor dynamics

Mukulika Ray, Julia Zaborowsky, Pranav Mahableshwarkar, Smriti Vaidyanathan, Jasmine Shum, Annie Huang, Renjith Viswanathan, Isabelle Pilo, Victoria Chen, Kaitlyn Cortez, Ashley Mae Conard, Szu‐Huan Wang, Victoria Johnson, Noah Wake, Alexander E. Conicella, , Erica Larschan

The paper shows CLAMP, a DNA-binding factor, regulates sex-specific splicing by interacting with RNA and modulating RBP dynamics.

bioRxiv · Jan 11, 2024 · PreprintGenomics

CLAMP and Zelda function together to promote Drosophila zygotic genome activation

Jingyue Ellie Duan, Leila E. Rieder, Megan M Colonnetta, Annie Huang, Mary Mckenney, Scott Watters, Girish Deshpande, William T. Jordan, Nicolas Lux Fawzi, Erica Larschan

The paper shows that CLAMP and Zelda work together to drive zygotic genome activation in Drosophila by enhancing chromatin accessibility and promoting transcription.

eLife · Aug 3, 2021Peer-reviewedGenomics