Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement via Single-Cell Genomics
Federica Sozza, Alberto Romano, Nicole D'Elia, Martina Terenzi, Maria Luisa Ratto, Emily R. Cliff, Gabrielle Nattenberg, S D Bianchi, Silvia Becca, Heather Klug, Davide Cacchiarelli, Elisa Balmas, Jesse G. Zalatan, Alessandro Bertero
The paper introduces CIRI, a CRISPR-based platform for programmable cell fate conversion in hiPSCs, using single-cell genomics to identify regulatory factors for myogenic differentiation.
bioRxiv · Jun 1, 2026 · PreprintSynthetic Biology