Cancer BiologybioRxivPreprint
Oncogene-driven metabolic regulation of Dihydroceramide Desaturase 1 (DES1) converges on GAPDH in matrix-detached conditions
Danielle Lambadis, Victoria Franzi, Deanna M Peperno…·Christopher J. Clarke
This study identifies a novel pathway where oncogenic PI3K pathway drives DES1 activity through GAPDH in matrix-detached conditions, linking glucose and sphingolipid metabolism.
DOI 10.64898/2026.06.18.733233