Author

Andrew E Resnick

Stony Brook UniversityORCID 0000-0002-6962-7712Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Christopher J. ClarkeiD· 3 shared Deanna M Peperno· 2 shared Fabiola Noelia VelazqueziD· 2 shared Janet J. Allopenna· 2 shared Jowana Obeid· 2 shared Mehdi DamaghiiD· 2 shared Victoria Franzi· 2 shared Yusuf Awni HannuniD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

Christopher J. ClarkeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor Growth

Andrew E Resnick, Victoria Franzi, Botheina Ghandour, Sam B Chiappone, Sébastien Lalanne, Monica Alexander, Deanna M Peperno, Jowana Obeid, Ishmam Pritam, Ian D Miranda, Nicolas Coant, Michael V. Airola, Mehdi Damaghi, Fabiola Noelia Velazquez, Yusuf Awni Hannun, Christopher J. Clarke

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

bioRxiv · Jul 4, 2026 · PreprintCancer Biology

Oncogene-driven metabolic regulation of Dihydroceramide Desaturase 1 (DES1) converges on GAPDH in matrix-detached conditions

Danielle Lambadis, Victoria Franzi, Deanna M Peperno, Ryan W. Linzer, Jonathan Aminov, Hector R Romero Garcia, Charly N Campanella, Andrew E Resnick, Folnetti A. Alvarez, Janet J. Allopenna, Christopher J. Clarke

This study identifies a novel pathway where oncogenic PI3K pathway drives DES1 activity through GAPDH in matrix-detached conditions, linking glucose and sphingolipid metabolism.

bioRxiv · Jun 20, 2026 · PreprintCancer Biology

Metabolic plasticity enables cancer adaptation to acidic tumor ecosystems

Raafat Chalar, Naheel Khatri, Jowana Obeid, Joon-Hyun Song, Yujie Xiao, Saiful Samad, A Chen, Andrew E Resnick, K H Karbalaei, Janet J. Allopenna, Cungui Mao, Christopher J. Clarke, Fabiola Noelia Velazquez, Bo Chen, Daniel Canals, , Mehdi Damaghi

This study shows cancer cells adapt to acidic tumor environments through sphingolipid metabolic plasticity, revealing that targeting metabolic flexibility, not individual pathways, may be more effective.

bioRxiv · May 5, 2026 · PreprintCancer Biology