Author

Folnetti A. Alvarez

Stony Brook UniversityORCID 0000-0002-6973-8957Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Christopher J. ClarkeiD· 2 shared Danielle Lambadis· 2 shared Victoria Franzi· 2 shared Achraf A. ShamseddineiD· 1 shared Andrew E ResnickiD· 1 shared Anne G. Ostermeyer‐Fay· 1 shared Ashley J. SnideriD· 1 shared Charly N Campanella· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Christopher J. ClarkeORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Oncogene-driven metabolic regulation of Dihydroceramide Desaturase 1 (DES1) converges on GAPDH in matrix-detached conditions

Danielle Lambadis, Victoria Franzi, Deanna M Peperno, Ryan W. Linzer, Jonathan Aminov, Hector R Romero Garcia, Charly N Campanella, Andrew E Resnick, Folnetti A. Alvarez, Janet J. Allopenna, Christopher J. Clarke

This study identifies a novel pathway where oncogenic PI3K pathway drives DES1 activity through GAPDH in matrix-detached conditions, linking glucose and sphingolipid metabolism.

bioRxiv · Jun 20, 2026 · PreprintCancer Biology

A Critical Role for Neutral Sphingomyelinase-2 in Doxorubicin-induced Cardiotoxicity

Samia Mohammed, Victoria Franzi, Yaping Jiang, Fabiola Noelia Velazquez, Monica E. Alexander, Folnetti A. Alvarez, Danielle Lambadis, Sam B Chiappone, Anne G. Ostermeyer‐Fay, Leiqing Zhang, Achraf A. Shamseddine, Daniel Canals, Ashley J. Snider, Richard Z. Lin, Yusuf Awni Hannun, Christopher J. Clarke

This study identifies nSMase2 as a critical mediator of Doxorubicin-induced cardiotoxicity and shows its loss protects against cardiac damage.

bioRxiv · Mar 20, 2025 · PreprintCell Biology