Author

Victoria Franzi

Stony Brook University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Christopher J. ClarkeiD· 3 shared Andrew E ResnickiD· 2 shared Danielle Lambadis· 2 shared Deanna M Peperno· 2 shared Fabiola Noelia VelazqueziD· 2 shared Folnetti A. AlvareziD· 2 shared Sam B Chiappone· 2 shared Yusuf Awni HannuniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

Christopher J. ClarkeORCID

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Author profile →

3 papers

Recent·Most cited

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor Growth

Andrew E Resnick, Victoria Franzi, Botheina Ghandour, Sam B Chiappone, Sébastien Lalanne, Monica Alexander, Deanna M Peperno, Jowana Obeid, Ishmam Pritam, Ian D Miranda, Nicolas Coant, Michael V. Airola, Mehdi Damaghi, Fabiola Noelia Velazquez, Yusuf Awni Hannun, Christopher J. Clarke

This study identifies nSMase2 as a metabolic tumor suppressor in breast cancer by restraining TAZ and inhibiting tumorigenesis.

bioRxiv · Jul 4, 2026 · PreprintCancer Biology

Oncogene-driven metabolic regulation of Dihydroceramide Desaturase 1 (DES1) converges on GAPDH in matrix-detached conditions

Danielle Lambadis, Victoria Franzi, Deanna M Peperno, Ryan W. Linzer, Jonathan Aminov, Hector R Romero Garcia, Charly N Campanella, Andrew E Resnick, Folnetti A. Alvarez, Janet J. Allopenna, Christopher J. Clarke

This study identifies a novel pathway where oncogenic PI3K pathway drives DES1 activity through GAPDH in matrix-detached conditions, linking glucose and sphingolipid metabolism.

bioRxiv · Jun 20, 2026 · PreprintCancer Biology

A Critical Role for Neutral Sphingomyelinase-2 in Doxorubicin-induced Cardiotoxicity

Samia Mohammed, Victoria Franzi, Yaping Jiang, Fabiola Noelia Velazquez, Monica E. Alexander, Folnetti A. Alvarez, Danielle Lambadis, Sam B Chiappone, Anne G. Ostermeyer‐Fay, Leiqing Zhang, Achraf A. Shamseddine, Daniel Canals, Ashley J. Snider, Richard Z. Lin, Yusuf Awni Hannun, Christopher J. Clarke

This study identifies nSMase2 as a critical mediator of Doxorubicin-induced cardiotoxicity and shows its loss protects against cardiac damage.

bioRxiv · Mar 20, 2025 · PreprintCell Biology