Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy
Christos Panagiotis Lisgaras, Azahara Oliva, Sam McKenzie, John J. LaFrancois, Steven A. Siegelbaum, Helen E. Scharman
This study shows that real-time optogenetic silencing of hippocampal CA2 neurons reduces seizures, interictal EEG abnormalities, and social comorbidities in mouse models of temporal lobe epilepsy.
bioRxiv · Jan 15, 2023 · PreprintNeuroscience