Steven A. Siegelbaum

The paper investigates how dorsal and ventral hippocampal CA2 regions contribute to social memory of aversive versus non-aversive experiences in mice.

This study investigates how the hippocampal CA2 and CA1 regions encode social memories of pair-bonded mates versus novel individuals in California mice.

This paper shows that chemogenetic activation of hippocampal CA2 neurons increases seizure frequency and duration in a mouse model of epilepsy.

This study investigates the role of the dorsal CA2 hippocampal region in social aggression and novelty recognition memory, finding that dCA2 promotes aggression towards novel conspecifics through its ability to distinguish novelty.

This study identifies a ventral CA2 region in the hippocampus that promotes social aggression but not social memory, distinguishing it from the dorsal CA2 region.

The paper investigates inhibitory deficits in the hippocampal CA2 region of a mouse model of temporal lobe epilepsy, identifying reduced cholecystokinin-expressing interneurons and impaired inhibition.

This study identifies a neural mechanism in hippocampal CA2 neurons that enables discrimination between social threat and safety based on past aversive experiences.

This study shows that real-time optogenetic silencing of hippocampal CA2 neurons reduces seizures, interictal EEG abnormalities, and social comorbidities in mouse models of temporal lobe epilepsy.

This study investigates how HCN1 channels in parvalbumin-positive interneurons regulate GABA release in hippocampal CA1, showing that HCN1 enhances inhibitory transmission.

This study presents two genetic mouse models of HCN1 epileptic encephalopathy, showing seizure susceptibility and adverse drug responses, highlighting the need for tailored therapies.

The paper identifies a direct lateral entorhinal cortex to hippocampal CA2 circuit that conveys social information necessary for social memory, distinct from novelty detection pathways.

This study investigates the role of hippocampal CA2 region in seizure generation in a mouse model of temporal lobe epilepsy, finding that enhanced excitability and reduced inhibition in CA2 contribute to seizure activity.

This study investigates how hippocampal CA2 neurons represent familiar and novel individuals, finding that familiarity alters the geometric structure of neural representations to support different social memory processes.

The paper investigates how the hippocampal CA2 region encodes social odors and their associations, showing it enables social memory through specific neural representations and reward learning.

The paper investigates how hippocampal CA2 neurons encode social novelty and shows that disrupting this coding in a schizophrenia mouse model can be rescued by a TREK-1 antagonist.

This study shows that CA2 ripples during sleep replay social exploration experiences, and disrupting or enhancing these ripples affects social memory consolidation.