Sam McKenzie

The paper evaluates spike sorting errors in awake mice using ground-truth data and finds that false negatives increase significantly during bursting and spike overlaps, challenging conventional benchmarks.

The paper investigates NE release during seizures in a Dravet Syndrome mouse model, finding inhibited LC-NE neuron activity but increased NE release in downstream regions.

The paper introduces a P-DOpE probe that combines optogenetics and electrophysiology for in vivo monitoring, showing it amplifies noradrenergic signaling in the hippocampus under specific conditions.

The paper identifies epileptiform discharges as a critical feature in a preclinical model of FASD, showing their relationship to high-frequency oscillations in the retrosplenial cortex.

The paper uses in vivo electrophysiology and dimensionality reduction to show alcohol exposure reduces firing rates in thalamic neurons but increases hippocampal excitability in mice.

The paper investigates how event boundaries influence norepinephrine release and hippocampal neural representations in mice, finding that NE dynamics correlate with environmental changes and affect spatial coding.

The paper investigates the role of axo-axonic cells in controlling sharp wave-ripple events in the hippocampus by manipulating and monitoring these cells in behaving mice.

This paper describes a protocol for simultaneously perturbing and recording neural activity in chronically implanted rodents using LED silicon probes.

This study shows that real-time optogenetic silencing of hippocampal CA2 neurons reduces seizures, interictal EEG abnormalities, and social comorbidities in mouse models of temporal lobe epilepsy.

This study investigates how CBD modulates LPI-GPR55 signaling at excitatory and inhibitory synapses, showing its role in reducing seizure activity by blocking LPI's pro-excitatory effects and enhancing inhibitory synaptic strength.

This study shows that preexisting hippocampal network dynamics constrain the formation of novel place fields induced by optogenetic stimulation.

The paper identifies a subiculum-retrosplenial pathway that propagates hippocampal ripples to the neocortex, revealing brain state-dependent coupling and specific neuronal mechanisms.

The paper develops methods to fit mechanistic spiking circuit models to single-trial spike train data, achieving accurate parameter estimation and validation using synthetic and experimental data.