Christos Panagiotis Lisgaras

This paper shows that chemogenetic activation of hippocampal CA2 neurons increases seizure frequency and duration in a mouse model of epilepsy.

The paper compares interictal spikes (IIS) and high frequency oscillations (HFOs>250Hz) in preclinical Alzheimer's disease models, finding HFOs more frequent and occurring across more behavioral states.

This study identifies the dentate gyrus as the dominant site of interictal spikes in Alzheimer's disease models and shows that cholinergic control from the medial septum modulates these spikes during REM sleep.

The paper investigates inhibitory deficits in the hippocampal CA2 region of a mouse model of temporal lobe epilepsy, identifying reduced cholecystokinin-expressing interneurons and impaired inhibition.

This study shows that real-time optogenetic silencing of hippocampal CA2 neurons reduces seizures, interictal EEG abnormalities, and social comorbidities in mouse models of temporal lobe epilepsy.

This study shows high frequency oscillations (HFOs) occur in Alzheimer's disease mouse models and are not unique to epilepsy.

This paper demonstrates that a modified intrahippocampal kainic acid model in mice produces robust, frequent convulsive seizures with human-like onset patterns and high frequency oscillations.

This study examines how early-life status epilepticus affects adult hippocampal-entorhinal circuitry in vitro, finding altered high-frequency oscillations and interictal discharge patterns.