Dual-antigen Doggybone DNA vaccine induces potent anti-tumor immunity against immunosuppressive oral cancer
Grace Min Yi Tan, Chuan Wang, Maria Martina Meschis, Josephine F. Buckingham, Kue Peng Lim, Sok Ching Cheong, Gareth J. Thomas, Sungwon Kim, Lisa J. Caproni, Helen Horton, Christian H. H. Ottensmeier, Natalia Savelyeva
The paper develops a dual-antigen DNA vaccine, CaVac OPT, which enhances anti-tumor immunity in oral cancer by reprogramming the tumor microenvironment and improving response to anti-PD1 therapy.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology