Identification of pre-existing ubiquitous neoantigen-reactive tumor-infiltrating T-cells in a patient with metastatic pancreatic neuroendocrine tumor
Jean‐Benoit Tanis, Katy J. McCann, Francisco Emmanuel Castañeda-Castro, Jaya Thomas, A.G. Bailey, Prabhat Singh, Eve Currall, Lindsey Chudley, Hayley A. Simon, Ben Nicholas, Judith Cave, Arjun S. Takhar, Susanne Burdak‐Rothkamm, Stephen Philip Schoenberger, Jason Greenbaum, , Christian H. H. Ottensmeier
This study identifies a ubiquitous neoantigen-reactive T-cell response across multiple metastatic sites in a patient with pancreatic neuroendocrine tumor, supporting the use of mutation-sharing status for neoantigen selection in immunotherapy.
bioRxiv · Aug 4, 2026 · PreprintImmunology