Gareth J. Thomas

This study identifies developmental programmes driving cellular plasticity in lung adenocarcinoma, linking BM activation to poor prognosis and therapy resistance.

This paper develops HEiST, a deep learning method to infer spatial transcriptomes from H&E slides, identifies two prognostic Spatiotypes in HNSC, and shows they predict treatment response better than existing biomarkers.

The paper develops a dual-antigen DNA vaccine, CaVac OPT, which enhances anti-tumor immunity in oral cancer by reprogramming the tumor microenvironment and improving response to anti-PD1 therapy.

This study identifies an 11-amino-acid sequence in the integrin β6 subunit that regulates pancreatic cancer metastasis by affecting cell proliferation, migration, and invasion.

This study shows that Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and drives breast cancer invasion by coordinating matrix stiffness and transcriptional reprogramming.