Christian H. H. Ottensmeier

This study identifies a ubiquitous neoantigen-reactive T-cell response across multiple metastatic sites in a patient with pancreatic neuroendocrine tumor, supporting the use of mutation-sharing status for neoantigen selection in immunotherapy.

The paper identifies functional neoantigens in NSCLC patients using immunopeptidomics, achieving an 83% success rate in eliciting immune responses.

This study identifies developmental programmes driving cellular plasticity in lung adenocarcinoma, linking BM activation to poor prognosis and therapy resistance.

The paper develops a dual-antigen DNA vaccine, CaVac OPT, which enhances anti-tumor immunity in oral cancer by reprogramming the tumor microenvironment and improving response to anti-PD1 therapy.

The paper compares transcriptomic and proteomic expression between two NSCLC subtypes to identify potential therapeutic targets and biomarkers.