JWA deficiency accelerates aging through disrupting intestinal epithelial homeostasis via Notch1/PPARγ/Stat5 axis
Xiong Li, Jingwen Liu, Luman Wang, Yan Zhou, Yifan Wen, Kun Ding, Lu Zou, Xia Liu, Aiping Li, Yun Wang, Heling Fu, Min Huang, Guoxian Ding, Jianwei Zhou
This study identifies JWA as an aging-associated gene whose deficiency disrupts intestinal epithelial homeostasis and accelerates aging in mice through the Notch1/PPARγ/Stat5 axis.
bioRxiv · Jan 17, 2022 · PreprintDevelopmental Biology