Human colon stem cells are the principal epithelial responders to bacterial antigens
Maaike Hillegonda de Vries, Claartje Meddens, Hemme J. Hijma, Anne‐Claire Berrens, Suze A. Jansen, Berend A. P. Kooiman, Scott B. Snapper, Hans C. Clevers, Michal Mokrý, Ewart Kuijk, Edward E. S. Nieuwenhuis
The paper investigates how human intestinal epithelial cells respond to bacterial antigens, finding that stem cells are the primary responders and that WNT signaling plays a key role in regulating microbial responses.
bioRxiv · Feb 7, 2025 · PreprintImmunology