Edward E. S. Nieuwenhuis

The paper generates intestinal organoids from pediatric IBD patients and controls to study epithelial phenotypes linked to genetic drivers of the disease, identifying gene expression patterns and pathways associated with inflammation.

This study examines how different TTC7A missense mutations in pediatric IBD patients lead to distinct intestinal epithelial phenotypes.

The paper investigates how human intestinal epithelial cells respond to bacterial antigens, finding that stem cells are the primary responders and that WNT signaling plays a key role in regulating microbial responses.

This study develops hepatocyte-like liver organoids (HeLLOs) that closely mimic mature hepatocyte functions and outperform existing models in drug toxicity testing and disease modeling.

This paper introduces a fluorescent reporter system for evaluating and enhancing prime editing efficiency in genomic targets.

This paper demonstrates the use of prime editing to correct genetic mutations in patient-derived organoids, showing high efficiency and precision with minimal off-target effects.