Respiratory syncytial virus nonstructural protein 1 inhibits production of cytokines and chemokines by differentiated primary nasal epithelial cells cultured at air-liquid interface
Rosanne W. Koutstaal, Amadeo Munoz-Garcia, Nadine Ebert, Manon Flore Licheri, Anke J. Lakerveld, Hendrik-Jan Hamstra, Anne T. Gelderloos, Jørgen Martin de Jonge, Cécile A. C. M. van Els, Volker Thiel, Ronald Dijkman, Puck B. van Kasteren
This study shows RSV NS1 supports viral replication by inhibiting IFN production and chemokine secretion in nasal epithelial cells, using an ALI model for vaccine assessment.
Journal of Innate Immunity · Feb 27, 2026Peer-reviewedMicrobiology