Author

Umar Haris Iqbal

Icahn School of Medicine at Mount SinaiORCID 0000-0002-3049-4094Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 1 Assay:multiome· 1

Frequent Co-Authors

Eun‐Jeong YangiD· 2 shared Giulio Maria PasinettiiD· 2 shared Alyanna M. Popatia· 1 shared Chad SmithiD· 1 shared Emma Durocher· 1 shared Francis J. HermaniD· 1 shared Henry D. Wu· 1 shared James Murrough· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Eun‐Jeong YangORCID

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3 papers

Recent·Most cited

Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression in vitro and invivo

Shireesha Manturthi, Sara El‐Sahli, Yuxia Bo, Emma Durocher, Melanie Kirkby, Alyanna M. Popatia, Karan Mediratta, Redaet Daniel, Seung-Hwan Lee, Umar Haris Iqbal, Marceline Côté, Lisheng Wang, Suresh Gadde

This study develops nanoparticles that co-deliver siRNA and mRNA to simultaneously silence and restore gene/protein expression in vitro and in vivo.

ACS Nanoscience Au · Nov 15, 2024Peer-reviewedBioengineering

The bioactive dietary polyphenol preparation alleviates depression and anxiety-like behaviors by modulating the regional heterogeneity of microglia morphology.

Eun‐Jeong Yang, Tal Frolinger, Susan Westfall, Umar Haris Iqbal, James Murrough, Giulio Maria Pasinetti

This study shows that a grape-derived polyphenol preparation reduces depression and anxiety-like behaviors in mice by altering microglia morphology and modulating inflammatory pathways.

Molecular Nutrition & Food Research · Jul 13, 2023Peer-reviewedNeuroscience

Inflammasome mediated neuronal-microglial crosstalk: a therapeutic substrate for the familial C9orf72 variant of the frontotemporal dementia/amyotrophic lateral sclerosis

Kyle J. Trageser, Chad Smith, Eun‐Jeong Yang, Ruth Iban‐Arias, Tatsunori Oguchi, Maria Sebastian-Valverde, Umar Haris Iqbal, Henry D. Wu, Molly S. Estill, Md Al Rahim, Urdhva Raval, Francis J. Herman, Yong Jie Zhang, Leonard Petrucelli, Giulio Maria Pasinetti

This study investigates the role of the NLRP3 inflammasome in C9orf72 FTD/ALS pathogenesis, finding that its inhibition improves survival and reduces neurodegeneration.

bioRxiv · Jan 27, 2022 · PreprintNeuroscience