Structural basis for selective remdesivir incorporation by SARS-CoV-2 RNA polymerase, and S759A resistance
Calvin J. Gordon, M.F. Oliva, Hery W. Lee, Quinten Goovaerts, Brent De Wijngaert, Matthias Götte, Kalyan Das
This study investigates remdesivir incorporation by SARS-CoV-2 RNA polymerase and the S759A resistance mechanism using enzymatic assays, mass spectrometry, and cryo-EM.
bioRxiv · Sep 4, 2025 · PreprintBiochemistry