Author

Quinten Goovaerts

Rega Institute for Medical ResearchORCID 0000-0002-2168-1103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Kalyan DasiD· 3 shared Brent De WijngaertiD· 2 shared Abhimanyu Kumar SinghiD· 1 shared Annelies StevaertiD· 1 shared Arnout R. D. VoetiD· 1 shared Benjamin Van LoyiD· 1 shared Bert VanmecheleniD· 1 shared Besir KrasniqiiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

Kalyan DasORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 4, 2025

Structural basis for selective remdesivir incorporation by SARS-CoV-2 RNA polymerase, and S759A resistance

Calvin J. Gordon, M.F. Oliva, Hery W. Lee…·Kalyan Das

This study investigates remdesivir incorporation by SARS-CoV-2 RNA polymerase and the S759A resistance mechanism using enzymatic assays, mass spectrometry, and cryo-EM.

DOI 10.1101/2025.09.04.674295

virusstructural biology

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MicrobiologyPLoS PathogensPeer-reviewedFeb 11, 2025

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

Benjamin Van Loy, Eugènia Pujol, Kenichi Kamata…·Annelies Stevaert

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.

9 citationstop 3%

humanexperimental assay

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BiochemistryMolecular CellPeer-reviewedDec 2, 2024

Human mitochondrial RNA polymerase structures reveal transcription start-site and slippage mechanism

Jiayu Shen, Quinten Goovaerts, Yogeeshwar Ajjugal…·Smita S. Patel

The paper presents cryo-EM structures of human mitochondrial transcription initiation complexes, revealing mechanisms of start-site selection and slippage synthesis.

5 citations

humancryo-EM

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