Activation of innate immune signalling during development predisposes to inflammatory intestine and shortened lifespan
Kyoko Yamashita, Ayano Oi, Hina Kosakamoto, Toshitaka Yamauchi, Hibiki Kadoguchi, Takayuki Kuraishi, Masayuki Miura, Fumiaki Obata
This study shows that early-life activation of the IMD immune pathway in Drosophila larvae leads to altered adult physiology, including shortened lifespan and changes in gut microbiota.
Disease Models & Mechanisms · Jul 2, 2021Peer-reviewedGenetics