Masayuki Miura

The paper shows that Bruce, an autophagy-regulated inhibitor, suppresses Dcp-1 activity and wing tissue growth in Drosophila, independent of apoptotic pathways.

This study shows that aging in Cladonema medusae impairs tissue homeostasis and blastema-mediated regeneration, highlighting shared constraints on regenerative systems across metazoans.

The paper investigates the role of ERK/MAPK and Notch signaling in regulating distinct proliferative populations during jellyfish tentacle regeneration, finding ERK/MAPK promotes RSPC proliferation while Notch controls RHSC differentiation and proliferation balance.

The paper identifies fat body-derived humoral factors involved in Drosophila disc regeneration using a Golgi-specific labeling system and proteomics.

This study identifies an amino acid reabsorption mechanism in Drosophila Malpighian tubules that maintains systemic amino acid homeostasis despite their primary role in secretion.

This study identifies Maltase as a key mediator of developmental robustness in Drosophila by modulating glucose availability and insulin signaling.

The paper shows that repressive SAM biosynthesis in Drosophila germline inhibits HeT-A retrotransposon transcription via 6mA methylation.

The paper investigates how glycine N-methyltransferase (Gnmt) degradation via the nuclear ubiquitin-proteasome system regulates S-adenosylmethionine (SAM) levels in Drosophila fat body under SAM shortage conditions.

The paper identifies Fas3G as a protein that facilitates non-lethal caspase activation in Drosophila olfactory receptor neurons by sequestering Drice near the plasma membrane.

This study shows that activated Hippo pathway in Drosophila induces non-cell autonomous tumorigenesis through amino acid transporters and growth factors.

This study identifies caspase-7 as responsible for early-peaking caspase activity at the plasma membrane during apoptosis, which drives phosphatidylserine exposure and efferocytosis.

This study shows that BubR1 and Mad2 regulate midgut remodeling in Drosophila diapause by promoting cell cycle arrest in intestinal stem cells, which is essential for survival under adverse conditions.

This study identifies Attacin-D as a nonsecretory antimicrobial peptide that mediates immune-induced organ damage in Drosophila renal tubules upon Imd pathway activation.

This study shows that dietary zinc restriction in Drosophila extends lifespan and mimics the effects of amino acid restriction.

This study introduces highly regenerative species-specific genes into Drosophila to improve stem cell function and extend lifespan by enhancing gut barrier functions during aging.

The paper shows nutrient fluctuations induce dedifferentiation of enteroendocrine cells into intestinal stem cells in Drosophila, promoting adaptive intestinal growth.

The paper identifies distinct stem-like cell populations in the jellyfish Cladonema pacificum that contribute to tentacle regeneration through different roles in homeostasis and repair.

This study shows that early-life activation of the IMD immune pathway in Drosophila larvae leads to altered adult physiology, including shortened lifespan and changes in gut microbiota.