Fumiaki Obata

This study identifies an amino acid reabsorption mechanism in Drosophila Malpighian tubules that maintains systemic amino acid homeostasis despite their primary role in secretion.

This study shows that suppressing the GCN2-ATF4 pathway extends lifespan in flies, while its activation reduces lifespan, revealing a dual role in aging.

This study identifies two mechanisms by which Drosophila compensates for choline deficiency: a bacterial PC synthesis pathway and host-derived βmPC production from carnitine.

This study shows that larval protein restriction in Drosophila extends adult lifespan by reducing storage proteins, which control translation and are enriched in aromatic amino acids.

This study shows that the SLC36 transporter Pathetic in Drosophila blood-brain barrier glia regulates tumour growth under nutrient restriction by modulating mTor-S6K pathway activity.

The paper shows that dietary amino acid manipulation in marmosets affects serum metabolites and FGF21 levels, suggesting evolutionary conservation of the mechanism.

This study identifies Attacin-D as a nonsecretory antimicrobial peptide that mediates immune-induced organ damage in Drosophila renal tubules upon Imd pathway activation.

This study shows that dietary zinc restriction in Drosophila extends lifespan and mimics the effects of amino acid restriction.

This study shows that early-life activation of the IMD immune pathway in Drosophila larvae leads to altered adult physiology, including shortened lifespan and changes in gut microbiota.