Disruption of LEDGF/p75-directed integration derepresses antisensetranscription of the HIV-1 genome
Philip R. Tedbury, Darius Mahboubi, Maritza Puray‐Chavez, Raven Shah, Obiaara B. Ukah, Claudia C. Wahoski, Hind J. Fadel, Eric M. Poeschla, Xinlin Gao, William M. McFadden, Maria Gaitanidou, Nikolaos Kesesidis, Karen A. Kirby, Thomas H. Vanderford, Mamuka Kvaratskhelia, , Stefan G. Sarafianos
The paper shows that disrupting HIV-1 integrase interactions with LEDGF/p75 increases antisense RNA (asRNA) production in HIV-1 infected cells.
bioRxiv · Dec 6, 2024 · PreprintMicrobiology