Author

Philip R. Tedbury

Emory UniversityORCID 0000-0001-8151-4967Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Karen A. KirbyiD· 3 shared William M. McFaddeniD· 3 shared Huanchun Zhang· 2 shared S RavichandraniD· 2 shared Stefan G. SarafianosiD· 2 shared Xinyong CaiiD· 2 shared Zachary C. LorsoniD· 2 shared Zhengqiang WangiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

Karen A. KirbyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural, biophysical, and virological mechanistic characterization of HIV-1 capsid-targeting antivirals

Karen A. Kirby, William M. McFadden, Lin Wang, Haijuan Du, Huanchun Zhang, Andres Emanuelli Castaner, Zachary C. Lorson, Arvin Nafisi, Anastasia Selyutina, Charlotte Luchsinger, Atsuko Hachiya, Maria E. Cilento, Alexa A. Snyder, S Ravichandran, Xinyong Cai, , Stefan G. Sarafianos

The paper characterizes structural, biophysical, and virological properties of HIV-1 capsid-targeting antivirals, showing improved potency and stability through chemical modifications of PF74.

bioRxiv · Mar 25, 2026 · PreprintBiochemistry

Design, synthesis and profiling of highly potent antivirals targeting emerging drug-resistant HIV-1 variants

Nicolas Jamey, D.M. Nirosh Udayanga, Huanchun Zhang, S Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Roshan A. Katekar, Jiashu Xie, Karen A. Kirby, Philip R. Tedbury, Zhengqiang Wang

This paper designs and synthesizes LEN analogs with improved potency against HIV-1 and resistant variants like M66I, showing significant enhancement in antiviral activity.

bioRxiv · Dec 30, 2025 · PreprintMicrobiology

Disruption of LEDGF/p75-directed integration derepresses antisensetranscription of the HIV-1 genome

Philip R. Tedbury, Darius Mahboubi, Maritza Puray‐Chavez, Raven Shah, Obiaara B. Ukah, Claudia C. Wahoski, Hind J. Fadel, Eric M. Poeschla, Xinlin Gao, William M. McFadden, Maria Gaitanidou, Nikolaos Kesesidis, Karen A. Kirby, Thomas H. Vanderford, Mamuka Kvaratskhelia, , Stefan G. Sarafianos

The paper shows that disrupting HIV-1 integrase interactions with LEDGF/p75 increases antisense RNA (asRNA) production in HIV-1 infected cells.

bioRxiv · Dec 6, 2024 · PreprintMicrobiology