Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling
Elke M. Muntjewerff, Dali Epremidze, Mariya Nezhyva, Satadeepa Kal, Theresa V. Rohm, Kechun Tang, Kailash Nath Singh, Daniel Espes, Suborno Jati, Marleen Bootsma, Atef Mahmoud Mannaa, Hiromi Ikebuchi, Anna Matilda Nilsson, Mahadevan Raj Rajasekaran, Per E. Andrén, , Gustaf Christoffersson
This study investigates the roles of CgA and its derived peptides, CST and PST, in pancreatic islet function and glucose homeostasis using knockout mice, revealing their opposing effects on insulin resistance and metabolic processes.
Communications Biology · Nov 26, 2025Peer-reviewedImmunology