Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing's syndrome
Mitchell H. Omar, Dominic P. Byrne, Kiana N. Jones, Tyler M. Lakey, Kerrie B. Collins, Kyung‐Soon Lee, Leonard A. Daly, Katherine A. Forbush, Ho-Tak Lau, Martin G. Golkowski, G. Stanley McKnight, David T. Breault, Anne‐Marie Lefrançois‐Martinez, Antoine Martinez, Claire E. Eyers, , John D. Scott
The paper shows that mutations in PKAc cause displacement from AKAP signaling islands, leading to distinct pathogenic signaling pathways in Cushing's syndrome.
bioRxiv · Oct 18, 2021 · PreprintMolecular Biology