Author

John D. Scott

University of WashingtonORCID 0000-0002-0367-8146Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Shao‐En OngiD· 2 shared Albert A. Kwong· 1 shared Anne‐Marie Lefrançois‐MartineziD· 1 shared Antoine MartineziD· 1 shared Claire E. EyersiD· 1 shared David T. BreaultiD· 1 shared Dominic P. ByrneiD· 1 shared F. Donelson SmithiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Shao‐En OngORCID

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2 papers

Recent·Most cited

Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma

Nicole M. Marsh, Melissa J. S. MacEwen, Jane Chea, Heidi L. Kenerson, Albert A. Kwong, Timothy M. Locke, Francisco Javier Miralles, Tanmay Sapre, Natasha Gozali, Madeleine L. Hart, Theo K. Bammler, James W. MacDonald, Lucas B. Sullivan, Gunes Ekin Atilla‐Gokcumen, Shao‐En Ong, , Yasemin Sancak

This study shows that mitochondrial calcium signaling regulates branched-chain amino acid catabolism and the urea cycle in fibrolamellar carcinoma through transcriptional control of metabolic genes.

Science Advances · May 28, 2025Peer-reviewedCell Biology

Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing's syndrome

Mitchell H. Omar, Dominic P. Byrne, Kiana N. Jones, Tyler M. Lakey, Kerrie B. Collins, Kyung‐Soon Lee, Leonard A. Daly, Katherine A. Forbush, Ho-Tak Lau, Martin G. Golkowski, G. Stanley McKnight, David T. Breault, Anne‐Marie Lefrançois‐Martinez, Antoine Martinez, Claire E. Eyers, , John D. Scott

The paper shows that mutations in PKAc cause displacement from AKAP signaling islands, leading to distinct pathogenic signaling pathways in Cushing's syndrome.

bioRxiv · Oct 18, 2021 · PreprintMolecular Biology