FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55/PP2A phosphatase
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison Kurimchak, Seren M. Palacio, Holly A. Fowle, Brennan C McEwan, Qifang Xu, Ziran Zhao, Lauren E. Cressey, Neil Johnson, James S. Duncan, Arminja Nadine Kettenbach, Roland L. Dunbrack, Xavier Graña
This paper identifies FAM122A as a SLiM-dependent inhibitor of B55/PP2A that competes with substrates to regulate cell cycle progression and checkpoint control.
bioRxiv · Mar 6, 2023 · PreprintMolecular Biology