Author

Brennan C McEwan

Dartmouth Cancer CenterORCID 0000-0002-9545-1087Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Arminja Nadine KettenbachiD· 2 shared A. Arockia Jeyaprakash· 1 shared Alison KurimchakiD· 1 shared Blanca Lopez MendeziD· 1 shared Bulat FaezoviD· 1 shared Camilla B. Chan· 1 shared Dimitriya Hristoforova Garvanska· 1 shared Holly A. Fowle· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Arminja Nadine KettenbachORCID

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2 papers

Recent·Most cited

Substrate recognition principles for the PP2A-B55 protein phosphatase

Thomas Kruse, Dimitriya Hristoforova Garvanska, Julia K. Varga, William Garland, Brennan C McEwan, Jamin B. Hein, Melanie Bianca Weisser, Iker Benavides-Puy, Camilla B. Chan, Paula Sotelo‐Parrilla, Blanca Lopez Mendez, A. Arockia Jeyaprakash, Ora Schueler‐Furman, Torben Heick Jensen, Arminja Nadine Kettenbach, Jakob Nilsson

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

Science Advances · Oct 2, 2024Peer-reviewedCell Biology

FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55/PP2A phosphatase

Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison Kurimchak, Seren M. Palacio, Holly A. Fowle, Brennan C McEwan, Qifang Xu, Ziran Zhao, Lauren E. Cressey, Neil Johnson, James S. Duncan, Arminja Nadine Kettenbach, Roland L. Dunbrack, Xavier Graña

This paper identifies FAM122A as a SLiM-dependent inhibitor of B55/PP2A that competes with substrates to regulate cell cycle progression and checkpoint control.

bioRxiv · Mar 6, 2023 · PreprintMolecular Biology