TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury
Melissa S. Rotunno, Megan Fowler, Jianjun Zhong, Kennedy O’Hara, Elenore Wiggin, Debra Cameron, Karly M. Stallworth, James Bouley, Holly R McEachern, Mina N. Anadolu, Jeffrey A. Nickerson, Andrew R. Tapper, Susanna Molas, Francesca Massi, Nils Henninger, , Daryl A. Bosco
This study shows that TDP-43 dysfunction impairs proteostasis and worsens neurological outcomes after brain injury in mice.
bioRxiv · Oct 20, 2025 · PreprintNeuroscience