Andrew R. Tapper

Arc Capsids Facilitate the Transfer of Muscleblind.

This paper shows Arc interacts with Mbnl1 RNA in a neuronal activity-dependent manner, facilitating transsynaptic transfer of Mbnl1 RNA through extracellular vesicles in Drosophila and mammals.

TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

This study shows that TDP-43 dysfunction impairs proteostasis and worsens neurological outcomes after brain injury in mice.

An orbitocortical-thalamic circuit suppresses binge alcohol-drinking.

The paper identifies a GABAergic neuronal ensemble in the medial orbitofrontal cortex that suppresses binge alcohol drinking by projecting to the mediodorsal thalamus.

Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse

The paper shows that Cre recombinase can be transported from somatic tissues to the male reproductive tract in mice, suggesting inter-tissue RNA or protein trafficking.

Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.