Mina N. Anadolu

This study shows that TDP-43 dysfunction impairs proteostasis and worsens neurological outcomes after brain injury in mice.

The paper shows that puromycylated peptides remain in neuronal ribosomes in a hybrid state, revealing a distinct conformation and stalling mechanism in neurons.

The paper identifies mRNA sequences that stall ribosomes in neurons, linking these sequences to FMRP association and stalled polysome function.