Author

Melissa S. Rotunno

University of Massachusetts Chan Medical SchoolORCID 0009-0004-5294-8634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Daryl A. BoscoiD· 2 shared Debra Cameron· 2 shared Francesca MassiiD· 2 shared Jeffrey A. NickersoniD· 2 shared Jianjun ZhongiD· 2 shared Karly M. Stallworth· 2 shared Megan FowleriD· 2 shared Andrew R. TapperiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Daryl A. BoscoORCID

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2 papers

Recent·Most cited

TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

Melissa S. Rotunno, Megan Fowler, Jianjun Zhong, Kennedy O’Hara, Elenore Wiggin, Debra Cameron, Karly M. Stallworth, James Bouley, Holly R McEachern, Mina N. Anadolu, Jeffrey A. Nickerson, Andrew R. Tapper, Susanna Molas, Francesca Massi, Nils Henninger, , Daryl A. Bosco

This study shows that TDP-43 dysfunction impairs proteostasis and worsens neurological outcomes after brain injury in mice.

bioRxiv · Oct 20, 2025 · PreprintNeuroscience

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly M. Stallworth, Debra Cameron, Melissa S. Rotunno, Pepper Dawes, Megan Fowler, Pamela J. Keagle, Justin A. McDonough, Sivakumar Boopathy, , Daryl A. Bosco

This study shows that ALS-linked PFN1 mutations impair vesicular degradation in iPSC-derived microglia by disrupting autophagy, which can be mitigated by Rapamycin.

Nature Communications · Mar 20, 2024Peer-reviewedNeuroscience