Author

Holly R. Hemesath

Institute for Bioscience and Biotechnology Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Approach:mechanistic / dynamical model· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

Ibrahim Damilare BoyenleiD· 2 shared Kathleen Joyce CarilloiD· 2 shared Lei ZhangiD· 2 shared Qiushi YeiD· 2 shared Yanxin LiuiD· 2 shared Angela WuiD· 1 shared Jaekyun Jeon· 1 shared John P. OrbaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

Ibrahim Damilare BoyenleORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 4, 2026

A Conserved Flexible N-Terminal Domain Tunes the Calcium Sensitivity of Sorcin by Stabilizing Its Active Conformation

Qiushi Ye, Angela Wu, Kathleen Joyce Carillo…·Yanxin Liu

This study identifies the flexible N-terminal domain of Sorcin as a critical regulator that enhances Ca2+ responsiveness by stabilizing its active conformation through dynamic contacts.

DOI 10.64898/2026.07.29.741579

humanprotein structure

𝕏 PostBluesky

BiophysicsbioRxivPreprintJul 9, 2026

Long-Timescale Molecular Dynamics Reveal a Coordination-Biased Conformational Selection Mechanism for Sorcin Activation

Qiushi Ye, Ibrahim Damilare Boyenle, Holly R. Hemesath…·Yanxin Liu

This study uses long-timescale molecular dynamics simulations to show that Ca2+ binding shifts pre-existing active states in Sorcin rather than inducing activation de novo.

1 citation

humanprotein structure

𝕏 PostBluesky