Lei Zhang

This study identifies the flexible N-terminal domain of Sorcin as a critical regulator that enhances Ca2+ responsiveness by stabilizing its active conformation through dynamic contacts.

This study uses long-timescale molecular dynamics simulations to show that Ca2+ binding shifts pre-existing active states in Sorcin rather than inducing activation de novo.

This paper identifies residue W230 as a dynamic gate in b0,+AT that regulates arginine transport through side chain flipping, using molecular dynamics simulations.

This study investigates calcium-induced Sorcin aggregation using stopped-flow light scattering, finding that aggregation is reversible, cooperative, and concentration-dependent.

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This study uses multilayered N-glycoproteomics to show impaired N-glycosylation in Alzheimer's disease mouse models, affecting protein function and neuronal health.