Yi Zhu

This study shows that Fc-FGF21's weight-loss efficacy depends on its circulating half-life, which is influenced by hTfR binding valency and BBB transport.

This study maps organ-specific endothelial surface proteomes in vivo to identify tissue-selective vascular targets for therapy.

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

This study identifies THIK-1 channel as a glucose sensor in microglia that modulates AgRP neuron activity and feeding behavior in diet-induced obesity.

This paper investigates 4-Methylumbelliferone's potential as a repurposed treatment for liver fibrosis, finding that it lacks efficacy at translatable doses and has an unclear mechanism.

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.