Regulation of fatty acid oxidation involved in high altitude hypoxia induced cardiomyocyte ferroptosis via the SIRT1-PPARα-GPX4 signaling pathway
Xiaona Song, Jie Chen, Hongbao Xu, Ling Zhang, Zirou Wang, Lingling Pu, Zhaoli Chen, Xinxing Wang, Weili Liu
This study identifies the SIRT1-PPARα-GPX4 pathway as a therapeutic target for high-altitude hypoxia-induced cardiac injury by regulating fatty acid oxidation and ferroptosis.
bioRxiv · Jan 20, 2025 · PreprintCell Biology