Cell BiologybioRxivPreprint
Regulation of fatty acid oxidation involved in high altitude hypoxia induced cardiomyocyte ferroptosis via the SIRT1-PPARα-GPX4 signaling pathway
Xiaona Song, Jie Chen, Hongbao Xu…·Weili Liu
This study identifies the SIRT1-PPARα-GPX4 pathway as a therapeutic target for high-altitude hypoxia-induced cardiac injury by regulating fatty acid oxidation and ferroptosis.
DOI 10.1101/2025.01.20.633884